Cunha And Mainoo To Start | 3-4-2-1 Manchester United Predicted Lineup Vs Brentford | OneFootball

Manchester United will clash heads with Brentford at the Gtech Community Stadium on Saturday afternoon as they look to secure a good result on the road in the Premier League. The Red Devils managed to earn a hard-fought 2-1 win against Chelsea recently, which should give them a ton of confidence ahead of this game.

Ruben Amorim will opt for the 3-4-2-1 formation and is expected to make some changes to his first XI for this clash. Both Matheus Cunha and Kobbie Mainoo could play from the start of this game.

3-4-2-1 Manchester United Predicted Lineup To Face Brentford

Defence

Altay Bayindir will feature in goal for the Red Devils after he conceded one goal in his last outing. Amorim will stick with the same back three of Matthijs de Ligt, Harry Maguire and Luke Shaw as they look to keep things solid on the defensive end of the field.

Leny Yoro will be available for selection on the bench as he offers cover for the defensive positions on the bench. However, Lisandro Martinez will miss this game because of a long-term injury.

MANCHESTER, ENGLAND – SEPTEMBER 20: Bruno Fernandes of Manchester United applauds the fans after the team’s victory in the Premier League match between Manchester United and Chelsea at Old Trafford on September 20, 2025 in Manchester, England. (Photo by Jan Kruger/Getty Images)

Midfield

Bruno Fernandes will partner up with Kobbie Mainoo as they look to win the 50-50 battles at the centre of the park. Patrick Dorgu will try to catch the eye on the left flank, while Noussair Mazraoui fills in as the right-sided wide player. Both of them will try to make some overlapping runs out in the wide areas.

Matheus Cunha and Bryan Mbeumo will operate as the free-flowing, attacking midfielders for Man United as they look to create some inviting chances in the final third.

Manuel Ugarte and Mason Mount will have to be content with a spot on the bench as they wait for their chance to influence the game in the second 45 minutes if needed. However, Diogo Dalot will miss this game due to a muscle injury.

Attack

Benjamin Sesko will lead the charge for the Mancunian giants up top. The Slovenian talent would be eager to find the back of the net after failing to score last weekend.

Joshua Zirkzee will have to settle for a spot on the bench and might come on to make an impact in the latter stages of the game if required.