Serie A official Week 25 line-ups: Napoli vs. Roma | OneFootball

Both Napoli and Roma are forced into changes for tonight’s Derby del Sole, but Rasmus Hojlund and Matteo Politano take on Donyell Malen and Bryan Zaragoza.

It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT (20.45 CET).

You can follow all the build-up and action as it happens from today’s Serie A games on the Liveblog.

NAPLES, ITALY – NOVEMBER 03: Gian Piero Gasperini Atalanta head coach greets Antonio Conte Napoli head coach beforeg the Serie A match between Napoli and Atalanta at Stadio Diego Armando Maradona on November 03, 2024 in Naples, Italy. (Photo by Francesco Pecoraro/Getty Images)

This was a Scudetto showdown a few weeks ago, but now feels more like a head-to-head for third place.

There are big absentees for both teams, as Scott McTominay has not yet recovered from the tendon inflammation that saw him limp off in the 3-2 win over Genoa.

He joins Giovanni Di Lorenzo, David Neres, Andre Frank Zambo Anguissa and Kevin De Bruyne in the stands, while Juan Jesus is suspended.

NAPLES, ITALY – FEBRUARY 10: Rasmus Hojlund of SSC Napoli gestures during the Coppa Italia match between SSC Napoli and Como 1907 at Stadio Diego Armando Maradona on February 10, 2026 in Naples, Italy. (Photo by Francesco Pecoraro/Getty Images)

Napoli didn’t rest midweek either, as they crashed out of the Coppa Italia in a sudden death penalty shoot-out against Como.

Eljif Elmas therefore drops down into midfield, but Politano has shaken off his injury to join Antonio Vergara and Hojlund in attack.

Sam Beukema steps into defence and Alessandro Buongiorno returns after his nightmare performance against Genoa.

CREMONA, ITALY – DECEMBER 28: Matteo Politano celebrates after the 0-2 goal during the Serie A match between US Cremonese and SSC Napoli at Stadio Giovanni Zini on December 28, 2025 in Cremona, Italy. (Photo by Marco M. Mantovani/Getty Images)

Roma have their own set of problems, as Paulo Dybala, Manu Kone, Artem Dovbyk, Evan Ferguson and Stephan El Shaarawy did not make the trip to Naples.

Matias Soulé is struggling with a recurring groin issue too, but so January signing Zaragoza gets his first start, joining Lorenzo Pellegrini to support fellow late arrival Malen.

The striker on loan from Aston Villa with option to buy has had a remarkable impact in Serie A, scoring three goals in his first four games.

He netted both in their 2-0 win over Cagliari on Monday, which ended a three-game winless streak in all competition.

As for the midfield, Nicolò Pisilli is preferred to Neil El Aynaoui, with Mario Hermoso not fully fit for the defence.

Bryan Zaragoza during his first interview with Roma.

Napoli vs. Roma line-ups

Napoli: Milinkovic-Savic; Beukema, Rrahmani, Buongiorno; Gutierrez, Lobotka, Elmas, Spinazzola; Politano, Vergara; Hojlund

Roma: Svilar; Mancini, Ndicka, Ghilardi; Celik, Cristante, Pisilli, Wesley; Pellegrini, Zaragoza; Malen

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Serie A Wk25 Liveblog including Napoli vs. Roma and Torino vs. Bologna