Manchester United vs Lyon: Europa League prediction, kick-off time, TV, live stream, team news, h2h results, odds | OneFootball

The Red Devils know winning the Europa League can salvage a disappointing season

Manchester United’s season is on the line when they host Lyon in their Europa League quarter-final second leg on Thursday night.

The tie is finely poised at 2-2 following a dramatic conclusion in France last week. Man Utd thought they had come from behind to earn a first leg lead, but a mistake in injury time from Andre Onana gifted Rayan Cherki an equaliser.

As a result, both sides know they have to win to avoid extra-time and possibly penalties.

Man United go into the game without a victory in four across all competitions and their preparations for the second leg have not gone well amid a huge injury blow and a 4-1 loss to Newcastle at the weekend.

Lyon, meanwhile, beat Auxerre away from home on Sunday to remain in the hunt for Champions League qualification through their position in Ligue 1.

Date, kick-off time and venue

Manchester United vs Lyon is scheduled for a 8pm BST kick-off on Thursday, April 17, 2025.

The match will take place at Old Trafford, Manchester.

Where to watch Manchester United vs Lyon

TV channel: In the UK, the game will be televised live on TNT Sports.

Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.

Live blog: You can follow all the action on matchday via Standard Sport’s live blog!

Manchester United vs Lyon team news

Man Utd will be without Joshua Zirkzee after he limped off clutching his hamstring shortly after half-time in the loss to Newcastle.

Furthermore, the Red Devils look set to remain without a host of other first-team regulars including Matthijs de Ligt, Amad Diallo, Lisandro Martinez, Ayden Heaven, Jonny Evans and Toby Collyer.

Ruben Amorim does have a big decision to make in goal after dropping Onana from the squad against the Magpies. Though, with Altay Bayindir not exactly staking his claim for a start, it could be that the Cameroon international earns an immediate recall.

Lyon can call upon former Arsenal pair Alexandre Lacazette and Ainsley Maitland-Niles. There could be a ‘Theatre of Dreams’ return for ex-United midfielder Nemanja Matic and his reception will be interesting given his comments regarding Onana last week.

Injury blow: Joshua Zirkzee

Getty Images

Manchester United vs Lyon prediction

Losing Zirkzee is a blow for Man United especially because Rasmus Hojlund has been out of sorts in recent weeks. Having said that, the striker has tended to save his better performances for the Europa League.

Similarly, United have found a formula in Europe that has seen them remain unbeaten in the competition up until this point, winning all their home games under Amorim and that record is set to continue.

Manchester United to win 2-1.

Head to head (h2h) history and results

Manchester United wins: 2

Draws: 3

Lyon wins: 0

Manchester United vs Lyon match odds

Manchester United to qualify: 4/11

Lyon to qualify: 21/10

Odds via Betfair (subject to change).