Serie A line-ups: Napoli vs. Empoli | OneFootball

Napoli look to Romelu Lukaku, David Neres and Matteo Politano for a must-win game against strugglers Empoli at the Stadio Maradona.

It kicks off at 20:45 CET (19:45 BST). It’s a must-win game for the Partenopei, who saw Inter move six points clear at the top of the table following Saturday’s 3-1 home win over Cagliari.

You can follow all the build-up and action as it happens from today’s five Serie A games on the Liveblog.

Giovanni Di Lorenzo and Zambo Anguissa are suspended for the home side, while Alessandro Buongiorno is injured.

Juan Jesus replaces the Italian centre-back, joining Amir Rrahmani, while Pasquale Mazzocchi starts in the right-back position.

Billy Gilmour starts in the middle of the park in place of Anguissa, joining his Scottish compatriot Scott McTominay and Stanislav Lobotka.

Politano and David Neres are the Napoli wingers providing support to Lukaku.

Empoli must cope without the injured Pellegri, Sazonov, Haas, Zurkowski, Maleh, Anjorin, Ismajli and Kouamé.

Sebastiano Esposito starts in attack for the Tuscans, who have not won a single Serie A match in 2025 but need a win tonight to escape the relegation zone.

Luca Marianucci starts as one of Empoli’s centre-backs, facing his future club as the promising defender will join Napoli in 2025-26.

Napoli (4-3-3): Meret; Mazzocchi, Rrahmani, Juan Jesus, Olivera; McTominay, Lobotka, Gilmour; Politano, Lukaku, Neres.

Empoli (3-4-2-1): Vasquez; Goglichidze, Marianucci, Viti; Gyasi, Henderson, Grassi, Pezzella; Fazzini, Cacace; Esposito.